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MX TECHNOLOGY

Sweet
Technology

MX is the first technology to leverage the benefits of Manuka honey without its limitations to unlock a highly demanded, triple-action impact on the key offenders preventing healing.*

*The claims resulting from in vitro testing have not been reviewed by the FDA and are not considered within the current cleared indications. 

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NATURAL BENEFITS

Manuka honey is a short term, non-contained, messy ingredient. MX is the first to retain benefits of honey and “unmess” it by incorporating Manuka honey into longer term, contained, solid formats and intentionally partnering it with the added benefits of gelatin and hydroxyapetite. 

PROVEN MATERIALS

Gelatin [1]
  • A natural protein matrix

  • Beneficial for cell migration, adhesion, and proliferation, essential for wound granulation and epithelialization

  • Attracts and buffers elevated levels of MMPs 

Manuka Honey [2]
  • Inhibits bacterial growth

  • Anti-inflammatory effect via suppression of MMP activity and neutrophil recruitment

  • Promotes healing by increasing fibroblast activity

Hydroxyapatite [3]
  • Binds proteins for cell attachment, proliferation, and differentiation

  • Promotes wound healing via angiogenesis and re-epithelialization

  • Promotes structural support to scaffolds

[1] Dantas et al. 2011; Li et al. 2014; Pezeshki-Modaress et al. 2014; Pezeshki-Modaress et al. 2015

[2] Sell et al. 2012; Afrin et al. 2018; Johnston et al. 2018; Minden-Birkenmaier et al. 2018

[3] Okabayashi et al. 2009; Majeed et al. 2012; Kawai et al. 2011; Weilin et al. 2016; Tommila et al.2008; Vilardell et al. 2016; Rodriguez et al. 2013 & 2016

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MX™ Technology Scientific Evidence

The presence of bacteria and the physiological imbalance between matrix metalloproteinases (MMPs) and growth factors can disrupt the normal wound healing cascade, resulting in a wound failing to heal.[4-7] At a cellular level, the following in vitro data demonstrates that MX™ Technology  has potential to reduce bacterial load,[8] decrease the secretion of MMP-9,[9] and trigger the release of growth factors,[9]  which has been shown to instill balance in the wound microenvironment[6, 10-12] and progress the wound towards healing [13] .

[4]  Bowler et al. 2001 

[5] Dickinson et al. 2016 

[6] Lobmann et al. 2002

[7] Barrientos et al. 2014

[8] Williams et al. 2021

[9] Rodriguez et al. 2021

[10] Muller et al. 2008

[11] Caley et al. 2015

[12] Bullen et al. 1995

[13] Yamakawa et al. 2019

The Phases of Wound Healing

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In the early stages of healing (the hemostasis and inflammatory phases), it is critical to reduce bacteria and inflammation.

In the later stages of healing (the proliferation and inflammatory phases), it is critical to maintain low levels of bacteria and inflammation while also increasing growth factors.

COMPLEX WOUND

HIGH BACTERIA

HIGH INFLAMMATION

LOW GROWTH FACTORS

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STALLING HEALING

HEALING WOUND

LOW BACTERIA

LOW INFLAMMATION

HIGH GROWTH FACTORS

PROGRESSING HEALING

BACTERIA REDUCTION Assessment

Staphylococcus Aureus
Pseudomonas Aeruginosa
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Growth Factor PRODUCTION

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MMP-9 PRODUCTION

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