MX™ is the first technology to leverage the benefits of Manuka honey without its limitations to unlock a highly demanded, triple-action impact on the key offenders preventing healing.*
*The claims resulting from in vitro testing have not been reviewed by the FDA and are not considered within the current cleared indications.
Manuka honey is a short term, non-contained, messy ingredient. MX™ is the first to retain benefits of honey and “unmess” it by incorporating Manuka honey into longer term, contained, solid formats and intentionally partnering it with the added benefits of gelatin and hydroxyapetite.
A natural protein matrix
Beneficial for cell migration, adhesion, and proliferation, essential for wound granulation and epithelialization
Attracts and buffers elevated levels of MMPs
Manuka Honey 
Inhibits bacterial growth
Anti-inflammatory effect via suppression of MMP activity and neutrophil recruitment
Promotes healing by increasing fibroblast activity
Binds proteins for cell attachment, proliferation, and differentiation
Promotes wound healing via angiogenesis and re-epithelialization
Promotes structural support to scaffolds
 Dantas et al. 2011; Li et al. 2014; Pezeshki-Modaress et al. 2014; Pezeshki-Modaress et al. 2015
 Sell et al. 2012; Afrin et al. 2018; Johnston et al. 2018; Minden-Birkenmaier et al. 2018
 Okabayashi et al. 2009; Majeed et al. 2012; Kawai et al. 2011; Weilin et al. 2016; Tommila et al.2008; Vilardell et al. 2016; Rodriguez et al. 2013 & 2016
MX™ Technology Scientific Evidence
The presence of bacteria and the physiological imbalance between matrix metalloproteinases (MMPs) and growth factors can disrupt the normal wound healing cascade, resulting in a wound failing to heal.[4-7] At a cellular level, the following in vitro data demonstrates that MX™ Technology has potential to reduce bacterial load, decrease the secretion of MMP-9, and trigger the release of growth factors, which has been shown to instill balance in the wound microenvironment[6, 10-12] and progress the wound towards healing  .
 Bowler et al. 2001
 Dickinson et al. 2016
 Lobmann et al. 2002
 Barrientos et al. 2014
 Williams et al. 2021
 Rodriguez et al. 2021
 Muller et al. 2008
 Caley et al. 2015
 Bullen et al. 1995
 Yamakawa et al. 2019
The Phases of Wound Healing
In the early stages of healing (the hemostasis and inflammatory phases), it is critical to reduce bacteria and inflammation.
In the later stages of healing (the proliferation and inflammatory phases), it is critical to maintain low levels of bacteria and inflammation while also increasing growth factors.
LOW GROWTH FACTORS
HIGH GROWTH FACTORS